Ontology highlight
ABSTRACT:
SUBMITTER: Kong BY
PROVIDER: S-EPMC6097549 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Kong Benjamin Y BY Carlino Matteo S MS Menzies Alexander M AM
Melanoma management 20160212 1
BRAF inhibitors were among the first systemic therapies to show clinical benefit in metastatic melanoma. Here, we review the spectrum of BRAF mutations in melanoma, their role in oncogenesis, clinicopathological associations and response to treatment. The differing biology and clinical features of V600E- and V600K-mutated melanoma are outlined. The molecular changes associated with <i>BRAF</i> fusion genes and their response to targeted therapies, as well as the role of immunotherapy in treatmen ...[more]