Genetic thrombophilia variants and risk for preeclampsia among American Indians.

ABSTRACT: To determine the prevalence of thrombophilic genetic variants in an American Indian population and determine if they are associated with preeclampsia.A total of 87 cases, 165 controls and an additional 75 population-based controls were genotyped for two thrombophilic polymorphisms.The allelic prevalence of the factor V Leiden and 20210 G/A prothrombin variants in this population was 2.1% and 0.5% respectively. No statistically significant associations between these genetic variants and preeclampsia were found.The prevalence of thrombophilic variants is of possible public health significance for other morbidity; but perhaps not in relation to preeclampsia.

SUBMITTER: Best LG 

PROVIDER: S-EPMC6097878 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature