Ontology highlight
ABSTRACT:
SUBMITTER: Kang YC
PROVIDER: S-EPMC6098059 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Kang Young Cheol YC Son Minuk M Kang Sora S Im Suyeol S Piao Ying Y Lim Kwang Suk KS Song Min-Young MY Park Kang-Sik KS Kim Yong-Hee YH Pak Youngmi Kim YK
Experimental & molecular medicine 20180817 8
An excess of reactive oxygen species (ROS) relative to the antioxidant capacity causes oxidative stress, which plays a role in the development of Parkinson's disease (PD). Because mitochondria are both sites of ROS generation and targets of ROS damage, the delivery of antioxidants to mitochondria might prevent or alleviate PD. To transduce the antioxidant protein human metallothionein 1A (hMT1A) into mitochondria, we computationally designed a cell-penetrating artificial mitochondria-targeting p ...[more]