Inflammation is a key contributor to ovarian cancer cell seeding.
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ABSTRACT:
SUBMITTER: Jia D
PROVIDER: S-EPMC6098104 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Publications
Inflammation is a key contributor to ovarian cancer cell seeding.
Jia Dongyu D Nagaoka Yoshiko Y Katsumata Makoto M Orsulic Sandra S
Scientific reports 20180817 1
The incidence of ovarian cancer dramatically increases in early menopause but the factors contributing to cancer onset are unclear. Most ovarian cancers originate in the fallopian tube with subsequent implantation of malignant cells into the ovary. However, the events and conditions that lead to cancer cell implantation are unknown. To quantify which conditions are conducive to the seeding of cancer cells in an immunocompetent mouse model, we surgically implanted mouse ovarian cancer cells into ...[more]
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