Confirmation of GLRA3 as a susceptibility locus for albuminuria in Finnish patients with type 1 diabetes.
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ABSTRACT:
SUBMITTER: Sandholm N
PROVIDER: S-EPMC6098108 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
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Confirmation of GLRA3 as a susceptibility locus for albuminuria in Finnish patients with type 1 diabetes.
Sandholm Niina N Haukka Jani K JK Toppila Iiro I Valo Erkka E Harjutsalo Valma V Forsblom Carol C Groop Per-Henrik PH
Scientific reports 20180817 1
Urinary albumin excretion is an early sign of diabetic kidney disease, affecting every third individual with diabetes. Despite substantial estimated heritability, only variants in the GLRA3 gene have been genome-wide significantly associated (p-value < 5 × 10<sup>-8</sup>) with diabetic albuminuria, in Finnish individuals with type 1 diabetes; However, replication attempt in non-Finnish Europeans with type 1 diabetes showed nominally significant association in the opposite direction, suggesting ...[more]
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