Carbon dioxide dynamics in relation to neurological outcome in resuscitated out-of-hospital cardiac arrest patients: an exploratory Target Temperature Management Trial substudy.

ABSTRACT:

Background

Dyscarbia is common in out-of-hospital cardiac arrest (OHCA) patients and its association to neurological outcome is undetermined.

Methods

This is an exploratory post-hoc substudy of the Target Temperature Management (TTM) trial, including resuscitated OHCA patients, investigating the association between serial measurements of arterial partial carbon dioxide pressure (PaCO₂) and neurological outcome at 6 months, defined by the Cerebral Performance Category (CPC) scale, dichotomized to good outcome (CPC 1 and 2) and poor outcome (CPC 3-5). The effects of hypercapnia and hypocapnia, and the time-weighted mean PaCO₂ and absolute PaCO₂ difference were analyzed. Additionally, the association between mild hypercapnia (6.0-7.30 kPa) and n

SUBMITTER: Ebner F 

PROVIDER: S-EPMC6098627 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature