Multidomain intervention for the prevention of cognitive decline after stroke - a pooled patient-level data analysis.

ABSTRACT:

Background and purpose

The aim of this pooled patient-level data analysis was to test if multidomain interventions, addressing several modifiable vascular risk factors simultaneously, are more effective than usual post-stroke care for the prevention of cognitive decline after stroke.

Methods

This pooled patient-level data analysis included two randomized controlled trials using a multidomain approach to target vascular risk factors in stroke patients and cognition as primary outcome. Changes from baseline to 12 months in the trail making test (TMT)-A, TMT-B and 10-words test were analysed using stepwise backward linear mixed models with study as random factor. Two analyses were based on the intention-to-treat (ITT) principle using different imputation approaches and one was

SUBMITTER: Teuschl Y 

PROVIDER: S-EPMC6099341 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature