Proton-Pump Inhibitors and Long-Term Risk of Community-Acquired Pneumonia in Older Adults.

ABSTRACT:

Objectives

To estimate associations between long-term use of proton pump inhibitors (PPIs) and pneumonia incidence in older adults in primary care.

Design

Longitudinal analyses of electronic medical records.

Setting

England PARTICIPANTS: Individuals aged 60 and older in primary care receiving PPIs for 1 year or longer (N=75,050) and age- and sex-matched controls (N=75,050).

Measurements

Net hazard ratios for pneumonia incidence in Year 2 of treatment were estimated using the prior event rate ratio (PERR), which adjusts for pneumonia incidence differences before initiation of treatment. Inverse probability weighted models adjusted for 78 demographic, disease, medication, and healthcare usage measures.

Results

During the second year after initiating treatm

SUBMITTER: Zirk-Sadowski J 

PROVIDER: S-EPMC6099478 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature