Ontology highlight
ABSTRACT:
SUBMITTER: Hebsgaard JB
PROVIDER: S-EPMC6099507 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Hebsgaard Josephine B JB Pyke Charles C Yildirim Emre E Knudsen Lotte B LB Heegaard Steffen S Kvist Peter H PH
Diabetes, obesity & metabolism 20180524 9
Semaglutide is a human glucagon-like peptide-1 (GLP-1) analogue that is in development for the treatment of type 2 diabetes. In the pre-approval cardiovascular outcomes trial SUSTAIN 6, semaglutide was associated with a significant increase in the risk of diabetic retinopathy (DR) complications vs placebo. GLP-1 receptor (GLP-1R) expression has previously been demonstrated in the retina in animals and humans; however, antibodies used to detect expression have been documented to be non-specific a ...[more]