Ontology highlight
ABSTRACT:
SUBMITTER: Singh S
PROVIDER: S-EPMC6099549 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Singh Srishti S Lomelino Carrie L CL Mboge Mam Y MY Frost Susan C SC McKenna Robert R
Molecules (Basel, Switzerland) 20180430 5
Carbonic anhydrases (CAs) catalyze the reversible hydration of carbon dioxide to produce bicarbonate and a proton. Multiple CA isoforms are implicated in a range of diseases, including cancer. In solid tumors, continuously dividing cells create hypoxic conditions that eventually lead to an acidic microenvironment. Hypoxic tumor cells have different mechanisms in place to regulate and adjust the surrounding microenvironment for survival. These mechanisms include expression of CA isoform IX (CA IX ...[more]