Dataset Information

Separation of 44Sc from Natural Calcium Carbonate Targets for Synthesis of 44Sc-DOTATATE.

ABSTRACT: The rapid increase in applications of scandium isotopes in nuclear medicine requires new efficient production routes for these radioisotopes. Recently, irradiations of calcium in cyclotrons by ?, deuteron, and proton beams have been used. Therefore, effective post-irradiation separation and preconcentration of the radioactive scandium from the calcium matrix are important to obtain the pure final product in a relatively small volume. Nobias resin was used as a sorbent for effective separation of 44Sc from calcium targets. Separation was performed at pH 3 using a column containing 10 mg of resin. Scandium was eluted with 100 ?L of 2 mol L-1 HCl. Particular attention was paid to the reduction of calcium concentration, presence of metallic impurities, robustness and simple automation. 44Sc was separated with 94.9 ± 2.8% yield, with results in the range of 91.7?99.0%. Purity of the eluate was confirmed with ICP-OES determination of metallic impurities and >99% chelation efficiency with DOTATATE, followed by >36 h radiochemical stability of the complex. A wide range of optimal conditions and robustness to target variability and suspended matter facilitates the proposed method in automatic systems for scandium isotope separation and synthesis of scandium-labeled radiopharmaceuticals.

SUBMITTER: Kilian K

PROVIDER: S-EPMC6100303 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Separation of <sup>44</sup>Sc from Natural Calcium Carbonate Targets for Synthesis of <sup>44</sup>Sc-DOTATATE.

Kilian Krzysztof K Cheda Łukasz Ł Sitarz Mateusz M Szkliniarz Katarzyna K Choiński Jarosław J Stolarz Anna A

Molecules (Basel, Switzerland) 20180720 7

The rapid increase in applications of scandium isotopes in nuclear medicine requires new efficient production routes for these radioisotopes. Recently, irradiations of calcium in cyclotrons by α, deuteron, and proton beams have been used. Therefore, effective post-irradiation separation and preconcentration of the radioactive scandium from the calcium matrix are important to obtain the pure final product in a relatively small volume. Nobias resin was used as a sorbent for effective separation of ...[more]

PMID: 30036947

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Project description:Contemporary studies of self-healing polymer composites are based on microcapsules synthesized using synthetic and toxic polymers, biopolymers, etc. via methods such as in situ polymerization, electrospraying, and air atomization. Herein, we synthesized a healing agent, epoxy (EPX) encapsulated calcium carbonate (CC) microcapsules, which was used to prepare self-healing EPX composites as a protective coating for metals. The CC microcapsules were synthesized using two facile methods, namely, the soft-template method (STM) and the in situ emulsion method (EM). Microcapsules prepared using the STM (ST-CC) were synthesized using sodium dodecyl sulphate (SDS) surfactant micelles as the soft-template, while the microcapsules prepared using the EM (EM-CC) were synthesized in an oil-in-water (O/W) in situ emulsion. These prepared CC microcapsules were characterized using light microscopy (LMC), field emission scanning electron microscopy (FE-SEM), fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance spectroscopy (NMR), and thermogravimetric analysis (TGA). The synthesized ST-CC microcapsules were spherical in shape, with an average diameter of 2.5 μm and an average shell wall thickness of 650 nm, while EM-CC microcapsules had a near-spherical shape with an average diameter of 3.4 μm and an average shell wall thickness of 880 nm. The ST-CC capsules exhibited flake-like rough surfaces while EM-CC capsules showed smooth bulgy surfaces. The loading capacity of ST-CC and EM-CC microcapsules were estimated using TGA and found to be 11% and 36%, respectively. The FTIR and NMR spectra confirmed the EPX encapsulation and the unreactive nature of the loaded EPX with the inner walls of CC microcapsules. The synthesized CC microcapsules were further incorporated into an EPX matrix to prepare composite coatings with 10 (w/w%), 20 (w/w%), and 50 (w/w%) capsule loadings. The prepared EPX composite coatings were scratched and observed using FE-SEM and LMC to evaluate the release of encapsulated EPX inside the CC capsules, which is analogous to the healing behaviour. Moreover, EPX composite coatings with 20 (w/w%) and 50 (w/w%) of ST-CC showed better healing performances. Thus, it was observed that ST-CC microcapsules outperformed EM-CC. Additionally, the EPX/CC coatings showed remarkable self-healing properties by closing the gaps of the scratch surfaces. Thus, these formaldehyde-free, biocompatible, biodegradable, and non-toxic CC based EPX composite coatings hold great potential to be used as a protective coating for metal substrates. Primary results detected significant corrosion retardancy due to the self-healing coatings under an accelerated corrosion process, which was performed with a salt spray test.

Dataset Information

Separation of 44Sc from Natural Calcium Carbonate Targets for Synthesis of 44Sc-DOTATATE.

Publications

Separation of <sup>44</sup>Sc from Natural Calcium Carbonate Targets for Synthesis of <sup>44</sup>Sc-DOTATATE.

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