Ontology highlight
ABSTRACT:
SUBMITTER: Tarasova O
PROVIDER: S-EPMC6100360 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Tarasova Olga O Poroikov Vladimir V Veselovsky Alexander A
Molecules (Basel, Switzerland) 20180521 5
Currently, millions of people are living with human immunodeficiency virus type 1 (HIV-1), which causes acquired immunodeficiency syndrome. However, the spread of the HIV-1 resistance to antiviral agents is the major problem in the antiretroviral therapy and medical management of HIV-infected patients. HIV-1 reverse transcriptase (RT) is one of the key viral targets for HIV-1 inhibition. Therefore, the studies on the combatting the HIV resistance that occurs due to the structural changes in RT, ...[more]