Ontology highlight
ABSTRACT:
SUBMITTER: Qiang X
PROVIDER: S-EPMC6100476 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Qiang Xiaoli X Kou Zheng Z Fang Gang G Wang Yanfeng Y
Molecules (Basel, Switzerland) 20180629 7
Avian influenza virus (AIV) can directly cross species barriers and infect humans with high fatality. Using machine learning methods, the present paper scores the amino acid mutations and predicts interspecies transmission. Initially, 183 signature positions in 11 viral proteins were screened by the scores of five amino acid factors and their random forest rankings. The most important amino acid factor (Factor 3) and the minimal range of signature positions (50 amino acid residues) were explored ...[more]