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First Metal-Free Synthesis of Tetracyclic Pyrido and Pyrazino Thienopyrimidinone Molecules.

ABSTRACT: We report herein a new metal free synthetic pathway to generate tetracyclic compounds from 3-aminothieno[3,2-b]pyridine-2-carboxylate. To enlarge the molecular diversity, we studied the Suzuki coupling of 9-chloro-6H-pyrido[1,2-a]pyrido[2',3':4,5]thieno[3,2-d]pyrimidin-6-one and several boronic acids were easily introduced.

SUBMITTER: Aounzou M

PROVIDER: S-EPMC6100531 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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First Metal-Free Synthesis of Tetracyclic Pyrido and Pyrazino Thienopyrimidinone Molecules.

Aounzou Mohammed M Campos Joana F JF Loubidi Mohammed M Berteina-Raboin Sabine S

Molecules (Basel, Switzerland) 20180511 5

We report herein a new metal free synthetic pathway to generate tetracyclic compounds from 3-aminothieno[3,2-b]pyridine-2-carboxylate. To enlarge the molecular diversity, we studied the Suzuki coupling of 9-chloro-6H-pyrido[1,2-a]pyrido[2',3':4,5]thieno[3,2-d]pyrimidin-6-one and several boronic acids were easily introduced. ...[more]

PMID: 29751677

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