Dataset Information

Proximal shift of colorectal cancer with increasing age in different ethnicities.

ABSTRACT:

Background

Studies have indicated a variation in colon cancer pathology with increased age. More findings have also suggested differences in genetics, biology, and demography in terms of ethnicity. Large-scale studies closely examining tumor location shift with aging and ethnicity are scarce.

Objective

We compared the tumor location shift with aging and the difference in survival based on tumor location by age group among the African-American, White, and Asian/Pacific Islander patients with colorectal cancer.

Materials and methods

We collected 270,390 cases from the Surveillance, Epidemiology, and End Results database between 2004 and 2014. Ethnicity distribution between younger (age <70 years) and older (age ?70 years) patients was analyzed using univariate and multivariate logistic regression. The Kaplan-Meier method was used to compare the tumor location survival difference in the African-American, White, and Asian/Pacific Islander patients.

Results

Larger tumors, female sex, M0, advanced N stage, no treatment, moderate to poor differentiation, total number of lymph nodes evaluated >12, and right-sided colon cancer were more common in patients aged ?70 years. More adverse prognosis was found in younger patients compared to older patients. Tumor location frequency differed based on age; the most pronounced differences were found in White patients. The right-sided colon cancer survival inferiority was present only in White patients.

Conclusion

Our findings support the premise of etiological and carcinogenic differences based on tumor location and between younger and older patients.

SUBMITTER: Yang L

PROVIDER: S-EPMC6101018 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Proximal shift of colorectal cancer with increasing age in different ethnicities.

Yang Lin L Xiong Zhenchong Z He Wenzhuo W Xie Kunqian K Liu Shousheng S Kong Pengfei P Jiang Chang C Guo Guifang G Xia Liangping L

Cancer management and research 20180815

<h4>Background</h4>Studies have indicated a variation in colon cancer pathology with increased age. More findings have also suggested differences in genetics, biology, and demography in terms of ethnicity. Large-scale studies closely examining tumor location shift with aging and ethnicity are scarce.<h4>Objective</h4>We compared the tumor location shift with aging and the difference in survival based on tumor location by age group among the African-American, White, and Asian/Pacific Islander pat ...[more]

PMID: 30147365

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Dataset Information

Proximal shift of colorectal cancer with increasing age in different ethnicities.

Background

Objective

Materials and methods

Results

Conclusion

Publications

Proximal shift of colorectal cancer with increasing age in different ethnicities.

Similar Datasets

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