Amyloid Beta Peptides Block New Synapse Assembly by Nogo Receptor-Mediated Inhibition of T-Type Calcium Channels.
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ABSTRACT:
SUBMITTER: Zhao Y
PROVIDER: S-EPMC6101033 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Publications
Amyloid Beta Peptides Block New Synapse Assembly by Nogo Receptor-Mediated Inhibition of T-Type Calcium Channels.
Zhao Yanjun Y Sivaji Sivaprakash S Chiang Michael C MC Ali Haadi H Zukowski Monica M Ali Sareen S Kennedy Bryan B Sklyar Alex A Cheng Alice A Guo Zihan Z Reed Alexander K AK Kodali Ravindra R Borowski Jennifer J Frost Georgia G Beukema Patrick P Wills Zachary P ZP
Neuron 20171001 2
Compelling evidence links amyloid beta (Aβ) peptide accumulation in the brains of Alzheimer's disease (AD) patients with the emergence of learning and memory deficits, yet a clear understanding of the events that drive this synaptic pathology are lacking. We present evidence that neurons exposed to Aβ are unable to form new synapses, resulting in learning deficits in vivo. We demonstrate the Nogo receptor family (NgR1-3) acts as Aβ receptors mediating an inhibition of synapse assembly, plasticit ...[more]
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