A generalized approach to predicting protein-protein interactions between virus and host.

ABSTRACT:

Background

Viral infection involves a large number of protein-protein interactions (PPIs) between virus and its host. These interactions range from the initial binding of viral coat proteins to host membrane receptor to the hijacking the host transcription machinery by viral proteins. Therefore, identifying PPIs between virus and its host helps understand the mechanism of viral infections and design antiviral drugs. Many computational methods have been developed to predict PPIs, but most of them are intended for PPIs within a species rather than PPIs across different species such as PPIs between virus and host.

Results

In this study, we developed a prediction model of virus-host PPIs, which is applicable to new viruses and hosts. We tested the prediction model on independent

SUBMITTER: Zhou X 

PROVIDER: S-EPMC6101077 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature