Ontology highlight
ABSTRACT:
SUBMITTER: Quereda V
PROVIDER: S-EPMC6102052 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Quereda Victor V Hou Shurong S Madoux Franck F Scampavia Louis L Spicer Timothy P TP Duckett Derek D
SLAS discovery : advancing life sciences R & D 20180511 8
Glioblastoma (GBM) is the most aggressive primary brain cancer with an average survival time after diagnosis of only 12-14 months, with few (<5%) long-term survivors. A growing body of work suggests that GBMs contain a small population of glioma stem cells (GSCs) that are thought to be major contributors to treatment resistance and disease relapse. Identifying compounds that modulate GSC proliferation would provide highly valuable molecular probes of GSC-directed signaling. However, targeting GS ...[more]