Ontology highlight
ABSTRACT:
SUBMITTER: Kwapis JL
PROVIDER: S-EPMC6102273 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Nature communications 20180820 1
Aging is accompanied by impairments in both circadian rhythmicity and long-term memory. Although it is clear that memory performance is affected by circadian cycling, it is unknown whether age-related disruption of the circadian clock causes impaired hippocampal memory. Here, we show that the repressive histone deacetylase HDAC3 restricts long-term memory, synaptic plasticity, and experience-induced expression of the circadian gene Per1 in the aging hippocampus without affecting rhythmic circadi ...[more]