Ontology highlight
ABSTRACT:
SUBMITTER: Yan L
PROVIDER: S-EPMC6102276 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Yan Li L Jiang Bin B Niu Yuyu Y Wang Hongxuan H Li Enqin E Yan Yaping Y Sun Huiyan H Duan Yanchao Y Chang Shaohui S Chen Guokai G Ji Weizhi W Xu Ren-He RH Si Wei W
Cell death discovery 20180820
Nonhuman primate experimental autoimmune encephalomyelitis (EAE) is a valuable model for multiple sclerosis, an inflammatory demyelinating disease in the central nervous system (CNS). Human embryonic stem cell-derived mesenchymal stem cells (EMSC) are effective in treating murine EAE. Yet, it remains unknown whether the EMSC efficacy is translatable to humans. Here we induced a primate EAE model in cynomolgus monkeys and delivered EMSC in spheres (EMSC<sub>sp</sub>) to preserve the cell viabilit ...[more]