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Control of metabolism by p53 - Cancer and beyond.

ABSTRACT: p53 is an important tumour suppressor gene, with loss of p53 contributing to the development of most human cancers. However, the activation of p53 in response to stress signals underpins a role for p53 in diverse aspects of health and disease. Activities of p53 that regulate metabolism can play a role in maintaining homeostasis and protecting cells from damage - so preventing disease development. By contrast, either loss or over-activation of p53 can contribute to numerous metabolic pathologies, including aging, obesity and diabetes.

SUBMITTER: Labuschagne CF

PROVIDER: S-EPMC6102416 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Control of metabolism by p53 - Cancer and beyond.

Labuschagne Christiaan F CF Zani Fabio F Vousden Karen H KH

Biochimica et biophysica acta. Reviews on cancer 20180605 1

p53 is an important tumour suppressor gene, with loss of p53 contributing to the development of most human cancers. However, the activation of p53 in response to stress signals underpins a role for p53 in diverse aspects of health and disease. Activities of p53 that regulate metabolism can play a role in maintaining homeostasis and protecting cells from damage - so preventing disease development. By contrast, either loss or over-activation of p53 can contribute to numerous metabolic pathologies, ...[more]

PMID: 29883595

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