Ontology highlight
ABSTRACT:
SUBMITTER: Zhang B
PROVIDER: S-EPMC6102594 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Zhang Bin B Guo Bingyi B Bai Yunlong Y Lu Huizhe H Dong Yanhong Y
Molecules (Basel, Switzerland) 20180504 5
Novel azamacrolides comprising the triazole moiety were synthesized and evaluated for their quorum sensing inhibitor activities on the <i>Agrobacterium tumefaciens</i>. It was found that the inhibition rate of compound <b>Z12</b>-<b>3</b> at 200 mg/L (0.45 mM) can reach 67%. The potential binding modes between these molecules and the TraR QS receptor was performed by molecular docking. The results showed that the two nitrogen atoms in the triazole ring of <b>Z12</b>-<b>3</b> formed hydrogen bond ...[more]