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Chromatogram-Bioactivity Correlation-Based Discovery and Identification of Three Bioactive Compounds Affecting Endothelial Function in Ginkgo Biloba Extract.


ABSTRACT: Discovery and identification of three bioactive compounds affecting endothelial function in Ginkgo biloba Extract (GBE) based on chromatogram-bioactivity correlation analysis. Three portions were separated from GBE via D101 macroporous resin and then re-combined to prepare nine GBE samples. 21 compounds in GBE samples were identified through UFLC-DAD-Q-TOF-MS/MS. Correlation analysis between compounds differences and endothelin-1 (ET-1) in vivo in nine GBE samples was conducted. The analysis results indicated that three bioactive compounds had close relevance to ET-1: Kaempferol-3-O-?-l-glucoside, 3-O-{2-O-{6-O-[P-OH-trans-cinnamoyl]-?-d-glucosyl}-?-rhamnosyl} Quercetin isomers, and 3-O-{2-O-{6-O-[P-OH-trans-cinnamoyl]-?-d-glucosyl}-?-rhamnosyl} Kaempferide. The discovery of bioactive compounds could provide references for the quality control and novel pharmaceuticals development of GRE. The present work proposes a feasible chromatogram-bioactivity correlation based approach to discover the compounds and define their bioactivities for the complex multi-component systems.

SUBMITTER: Liu H 

PROVIDER: S-EPMC6102599 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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Chromatogram-Bioactivity Correlation-Based Discovery and Identification of Three Bioactive Compounds Affecting Endothelial Function in Ginkgo Biloba Extract.

Liu Hong H   Tan Li-Ping LP   Huang Xin X   Liao Yi-Qiu YQ   Zhang Wei-Jian WJ   Li Pei-Bo PB   Wang Yong-Gang YG   Peng Wei W   Wu Zhong Z   Su Wei-Wei WW   Yao Hong-Liang HL  

Molecules (Basel, Switzerland) 20180503 5


Discovery and identification of three bioactive compounds affecting endothelial function in <i>Ginkgo biloba</i> Extract (GBE) based on chromatogram-bioactivity correlation analysis. Three portions were separated from GBE via D101 macroporous resin and then re-combined to prepare nine GBE samples. 21 compounds in GBE samples were identified through UFLC-DAD-Q-TOF-MS/MS. Correlation analysis between compounds differences and endothelin-1 (ET-1) in vivo in nine GBE samples was conducted. The analy  ...[more]

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