Bacterial zinc uptake regulator proteins and their regulons.
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ABSTRACT:
SUBMITTER: Mikhaylina A
PROVIDER: S-EPMC6103462 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Publications
Bacterial zinc uptake regulator proteins and their regulons.
Mikhaylina Alevtina A Ksibe Amira Z AZ Scanlan David J DJ Blindauer Claudia A CA
Biochemical Society transactions 20180731 4
All organisms must regulate the cellular uptake, efflux, and intracellular trafficking of essential elements, including d-block metal ions. In bacteria, such regulation is achieved by the action of metal-responsive transcriptional regulators. Among several families of zinc-responsive transcription factors, the 'zinc uptake regulator' Zur is the most widespread. Zur normally represses transcription in its zinc-bound form, in which DNA-binding affinity is enhanced allosterically. Experimental and ...[more]
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