Global expression profiling and pathway analysis of mouse mammary tumor reveals strain and stage specific dysregulated pathways in breast cancer progression.
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ABSTRACT:
SUBMITTER: Mei Y
PROVIDER: S-EPMC6103659 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
Global expression profiling and pathway analysis of mouse mammary tumor reveals strain and stage specific dysregulated pathways in breast cancer progression.
Mei Yan Y Yang Jun-Ping JP Lang Yan-Hong YH Peng Li-Xia LX Yang Ming-Ming MM Liu Qing Q Meng Dong-Fang DF Zheng Li-Sheng LS Qiang Yuan-Yuan YY Xu Liang L Li Chang-Zhi CZ Wei Wen-Wen WW Niu Ting T Peng Xing-Si XS Yang Qin Q Lin Fen F Hu Hao H Xu Hong-Fa HF Huang Bi-Jun BJ Wang Li-Jing LJ Qian Chao-Nan CN
Cell cycle (Georgetown, Tex.) 20180531 8
It is believed that the alteration of tissue microenvironment would affect cancer initiation and progression. However, little is known in terms of the underlying molecular mechanisms that would affect the initiation and progression of breast cancer. In the present study, we use two murine mammary tumor models with different speeds of tumor initiation and progression for whole genome expression profiling to reveal the involved genes and signaling pathways. The pathways regulating PI3K-Akt signali ...[more]
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