Ontology highlight
ABSTRACT:
SUBMITTER: Frimodt-Moller J
PROVIDER: S-EPMC6104031 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Frimodt-Møller Jakob J Rossi Elio E Haagensen Janus Anders Juul JAJ Falcone Marilena M Molin Søren S Johansen Helle Krogh HK
Scientific reports 20180821 1
In 474 genome sequenced Pseudomonas aeruginosa isolates from 34 cystic fibrosis (CF) patients, 40% of these harbor mutations in the mexZ gene encoding a negative regulator of the MexXY-OprM efflux pump associated with aminoglycoside and fluoroquinolone resistance. Surprisingly, resistance to aminoglycosides and fluoroquinolones of mexZ mutants was far below the breakpoint of clinical resistance. However, the fitness increase of the mutant bacteria in presence of the relevant antibiotics, as demo ...[more]