Ontology highlight
ABSTRACT:
SUBMITTER: Turner N
PROVIDER: S-EPMC6104039 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Nature communications 20180821 1
Specific forms of the lipid ceramide, synthesized by the ceramide synthase enzyme family, are believed to regulate metabolic physiology. Genetic mouse models have established C16 ceramide as a driver of insulin resistance in liver and adipose tissue. C18 ceramide, synthesized by ceramide synthase 1 (CerS1), is abundant in skeletal muscle and suggested to promote insulin resistance in humans. We herein describe the first isoform-specific ceramide synthase inhibitor, P053, which inhibits CerS1 wit ...[more]