Ontology highlight
ABSTRACT:
SUBMITTER: Frank A
PROVIDER: S-EPMC6104066 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Frank Annika A Kiss Dóra J DJ Keserű György M GM Stark Holger H
Scientific reports 20180821 1
The dissociation behaviours of aripiprazole and cariprazine at the human D<sub>2</sub> and D<sub>3</sub> receptor are evaluated. A potential correlation between kinetics and in vivo profiles, especially cariprazine's action on negative symptoms in schizophrenia, is investigated. The binding kinetics of four ligands were indirectly evaluated. After the receptor preparations were pre-incubated with the unlabelled ligands, the dissociation was initiated with an excess of [<sup>3</sup>H]spiperone. S ...[more]