The effects of phenolic glycosides from Betula platyphylla var. japonica on adipocyte differentiation and mature adipocyte metabolism.

ABSTRACT: Betula platyphylla var. japonica (Betulaceae) has been used traditionally in Asian countries for the treatment of inflammatory diseases. A recent study has reported a phenolic compound, platyphylloside from B. platyphylla, that shows inhibition on adipocyte differentiation and induces lipolysis in 3T3-L1 cells. Based on this finding, we conducted phytochemical analysis of the EtOH extract of the bark of B. platyphylla var. japonica, which resulted in the isolation of phenolic glycosides (1-4). Treatment of the isolated compounds (1-4) during adipocyte differentiation of 3T3-L1 mouse adipocytes resulted in dose-dependent inhibition of adipogenesis. In mature adipocytes, arylbutanoid glycosides (2-4) induced lipolysis related genes HSL and ATGL, whereas catechin glycoside (1) had no effect.

SUBMITTER: Huh JY 

PROVIDER: S-EPMC6104606 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature