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Risk of metabolic disorders in childless men: a population-based cohort study.

ABSTRACT: OBJECTIVE:To study whether male childlessness is associated with an increased risk of metabolic disorders such as metabolic syndrome (MetS) and diabetes. DESIGN:A population-based cohort study. SETTING:Not applicable. PARTICIPANTS:2572 men from the population-based Malmö Diet and Cancer Cardiovascular Cohort. INTERVENTIONS:None. MAIN OUTCOME MEASURES:From cross-sectional analyses, main outcome measures were ORs and 95% CIs for MetS and diabetes among childless men. In prospective analyses, HRs and 95% CI for diabetes among childless men. RESULTS:At baseline, in men with a mean age of 57 years, the prevalence of MetS was 26% and 22% among childless men and fathers, respectively. Similarly, we observed a higher prevalence of diabetes of 11% among childless men compared with 5% among fathers. In the cross-sectional adjusted analyses, childless men had a higher risk of MetS and diabetes, with ORs of 1.22 (95% CI 0.87 to 1.72) and 2.12 (95% CI 1.34 to 3.36) compared with fathers. In the prospective analysis, during a mean follow-up of 18.3 years, we did not see any increase in diabetes risk among childless men (HR 1.02 (0.76 to 1.37)). CONCLUSION:This study provides evidence of an association between male childlessness and a higher risk of MetS and diabetes. However, as these associations were found in cross-sectional analyses, reverse causation cannot be excluded.

SUBMITTER: Bungum AB

PROVIDER: S-EPMC6104745 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Risk of metabolic disorders in childless men: a population-based cohort study.

Bungum Ane Berger AB Glazer Clara Helene CH Bonde Jens Peter JP Nilsson Peter M PM Giwercman Aleksander A Søgaard Tøttenborg Sandra S

BMJ open 20180817 8

<h4>Objective</h4>To study whether male childlessness is associated with an increased risk of metabolic disorders such as metabolic syndrome (MetS) and diabetes.<h4>Design</h4>A population-based cohort study.<h4>Setting</h4>Not applicable.<h4>Participants</h4>2572 men from the population-based Malmö Diet and Cancer Cardiovascular Cohort.<h4>Interventions</h4>None.<h4>Main outcome measures</h4>From cross-sectional analyses, main outcome measures were ORs and 95% CIs for MetS and diabetes among ch ...[more]

PMID: 30121591

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Risk of metabolic disorders in childless men: a population-based cohort study.

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Risk of metabolic disorders in childless men: a population-based cohort study.

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