Small volume plasma exchange for Guillain-Barre syndrome in resource-limited settings: a phase II safety and feasibility study.

ABSTRACT:

Objective

To assess the safety and feasibility of small volume plasma exchange (SVPE) for patients with Guillain-Barré syndrome (GBS).

Design

Non-randomised, single-arm, interventional trial.

Setting

National Institute of Neurosciences and Hospital, Dhaka, Bangladesh.

Participants

Twenty adult (>18 years) patients with GBS presented within 2 weeks of onset of weakness who were unable to walk unaided for more than 10 m.

Interventions

SVPE involves blood cell sedimentation in a blood bag and removal of supernatant plasma after blood cells are retransfused. This procedure was repeated three to six times a day, for eight consecutive days. Fresh frozen plasma (FFP) and normal saline were used as replacement fluid.

Outcome measures

Serious adverse event

SUBMITTER: Islam B 

PROVIDER: S-EPMC6104782 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature