Ontology highlight
ABSTRACT:
SUBMITTER: Lehmann J
PROVIDER: S-EPMC6104829 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Lehmann Johannes J Cheng Tan-Yun TY Aggarwal Anup A Park Annie S AS Zeiler Evelyn E Raju Ravikiran M RM Akopian Tatos T Kandror Olga O Sacchettini James C JC Moody D Branch DB Rubin Eric J EJ Sieber Stephan A SA
Angewandte Chemie (International ed. in English) 20171205 1
The spread of antibiotic resistance is a major challenge for the treatment of Mycobacterium tuberculosis infections. In addition, the efficacy of drugs is often limited by the restricted permeability of the mycomembrane. Frontline antibiotics inhibit mycomembrane biosynthesis, leading to rapid cell death. Inspired by this mechanism, we exploited β-lactones as putative mycolic acid mimics to block serine hydrolases involved in their biosynthesis. Among a collection of β-lactones, we found one hit ...[more]