Ontology highlight
ABSTRACT:
SUBMITTER: Bassani F
PROVIDER: S-EPMC6105217 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Extremophiles : life under extreme conditions 20180725 5
Eukaryotic eIF5A and its bacterial orthologue EF-P are translation elongation factors whose task is to rescue ribosomes from stalling during the synthesis of proteins bearing particular sequences such as polyproline stretches. Both proteins are characterized by unique post-translational modifications, hypusination and lysinylation, respectively, which are essential for their function. An orthologue is present in all Archaea but its function is poorly understood. Here, we show that aIF5A of the c ...[more]