Ontology highlight
ABSTRACT:
SUBMITTER: Ghamari-Langroudi M
PROVIDER: S-EPMC6105298 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Science advances 20180822 8
Like most homeostatic systems, adiposity in mammals is defended between upper and lower boundary conditions. While leptin and melanocortin-4 receptor (MC4R) signaling are required for defending energy set point, mechanisms controlling upper and lower homeostatic boundaries are less well understood. In contrast to the MC4R, deletion of the MC3R does not produce measurable hyperphagia or hypometabolism under normal conditions. However, we demonstrate that MC3R is required bidirectionally for contr ...[more]