Stent thrombosis rates the first year and beyond with new- and old-generation drug-eluting stents compared to bare metal stents.

ABSTRACT:

Objectives

Old-generation drug-eluting coronary stents (o-DES) have despite being safe and effective been associated with an increased propensity of late stent thrombosis (ST). We evaluated ST rates in o-DES, new-generation DES (n-DES) and bare metal stents (BMS) the first year (?1 year).

Methods

We evaluated all implantations with BMS, o-DES (Cordis Cypher, Boston Scientific Taxus Liberté and Medtronic Endeavor) and n-DES in the Swedish coronary angiography and angioplasty registry (SCAAR) between 1 January 2007 and 8 January 2014 (n?=?207 291). All cases of ST (n?=?2 268) until 31 December 2014 were analyzed.

Results

The overall risk of ST was lower in both n-DES and o-DES compared with BMS up to 1 year (n-DES versus BMS: adjusted risk ratio (RR) 0.48 (0.41-0.58) and o-DES versus BMS: 0.56 (0.46-0.67), both p?ConclusionNew-generation DES were associated with lower ST rates in comparison to BMS during the first-year post-stenting. After 1 year, n-DES and BMS were associated with similar ST rates.

Trial registration

This study was a retrospective observational study and as such did not require clinical trial database registration.

SUBMITTER: Varenhorst C 

PROVIDER: S-EPMC6105307 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature