Ontology highlight
ABSTRACT:
SUBMITTER: Hartzell AL
PROVIDER: S-EPMC6105310 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Hartzell Andrea L AL Martyniuk Kelly M KM Brigidi G Stefano GS Heinz Daniel A DA Djaja Nathalie A NA Payne Anja A Bloodgood Brenda L BL
eLife 20180727
Experience-dependent expression of immediate-early gene transcription factors (IEG-TFs) can transiently change the transcriptome of active neurons and initiate persistent changes in cellular function. However, the impact of IEG-TFs on circuit connectivity and function is poorly understood. We investigate the specificity with which the IEG-TF NPAS4 governs experience-dependent changes in inhibitory synaptic input onto CA1 pyramidal neurons (PNs). We show that novel sensory experience selectively ...[more]