Low-Dose Anti-Thymocyte Globulin (ATG) Preserves β-Cell Function and Improves HbA_1c in New-Onset Type 1 Diabetes.

ABSTRACT:

Objective

A pilot study suggested that combination therapy with low-dose anti-thymocyte globulin (ATG) and pegylated granulocyte colony-stimulating factor (GCSF) preserves C-peptide in established type 1 diabetes (T1D) (duration 4 months to 2 years). We hypothesized that 1) low-dose ATG/GCSF or 2) low-dose ATG alone would slow the decline of β-cell function in patients with new-onset T1D (duration <100 days).

Research design and methods

A three-arm, randomized, double-masked, placebo-controlled trial was performed by the Type 1 Diabetes TrialNet Study Group in 89 subjects: 29 subjects randomized to ATG (2.5 mg/kg intravenously) followed by pegylated GCSF (6 mg subcutaneously every 2 weeks for 6 doses), 29 to ATG alone (2.5 mg/kg), and 31 to placebo. The primary

SUBMITTER: Haller MJ 

PROVIDER: S-EPMC6105329 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature