Ontology highlight
ABSTRACT:
SUBMITTER: Schrand B
PROVIDER: S-EPMC6105580 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Schrand Brett B Clark Emily E Levay Agata A Capote Ailem Rabasa AR Martinez Olivier O Brenneman Randall R Castro Iris I Gilboa Eli E
Nature communications 20180822 1
Uptake of tumor antigens by tumor-infiltrating dendritic cells is limiting step in the induction of tumor immunity, which can be mediated through Fc receptor (FcR) triggering by antibody-coated tumor cells. Here we describe an approach to potentiate tumor immunity whereby hapten-specific polyclonal antibodies are recruited to tumors by coating tumor cells with the hapten. Vaccination of mice against dinitrophenol (DNP) followed by systemic administration of DNP targeted to tumors by conjugation ...[more]