Ontology highlight
ABSTRACT:
SUBMITTER: Leger H
PROVIDER: S-EPMC6105603 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Léger Hélène H Santana Evelyn E Leu N Adrian NA Smith Eliot T ET Beltran William A WA Aguirre Gustavo D GD Luca Francis C FC
Scientific reports 20180822 1
Ndr2/Stk38l encodes a protein kinase associated with the Hippo tumor suppressor pathway and is mutated in a naturally-occurring canine early retinal degeneration (erd). To elucidate the retinal functions of Ndr2 and its paralog Ndr1/Stk38, we generated Ndr1 and Ndr2 single knockout mice. Although retinal lamination appeared normal in these mice, Ndr deletion caused a subset of Pax6-positive amacrine cells to proliferate in differentiated retinas, while concurrently decreasing the number of GABAe ...[more]