Ontology highlight
ABSTRACT:
SUBMITTER: Moran I
PROVIDER: S-EPMC6105623 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Moran Imogen I Nguyen Akira A Khoo Weng Hua WH Butt Danyal D Bourne Katherine K Young Clara C Hermes Jana R JR Biro Maté M Gracie Gary G Ma Cindy S CS Munier C Mee Ling CML Luciani Fabio F Zaunders John J Parker Andrew A Kelleher Anthony D AD Tangye Stuart G SG Croucher Peter I PI Brink Robert R Read Mark N MN Phan Tri Giang TG
Nature communications 20180822 1
Vaccine-induced immunity depends on the generation of memory B cells (MBC). However, where and how MBCs are reactivated to make neutralising antibodies remain unknown. Here we show that MBCs are prepositioned in a subcapsular niche in lymph nodes where, upon reactivation by antigen, they rapidly proliferate and differentiate into antibody-secreting plasma cells in the subcapsular proliferative foci (SPF). This novel structure is enriched for signals provided by T follicular helper cells and anti ...[more]