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Chromosomally Encoded mcr-5 in Colistin-Nonsusceptible Pseudomonas aeruginosa.

ABSTRACT: Whole-genome sequencing (WGS) of historical Pseudomonas aeruginosa clinical isolates identified a chromosomal copy of mcr-5 within a Tn3-like transposon in P. aeruginosa MRSN 12280. The isolate was nonsusceptible to colistin by broth microdilution, and genome analysis revealed no mutations known to confer colistin resistance. To the best of our knowledge, this is the first report of mcr in colistin-nonsusceptible P. aeruginosa.

SUBMITTER: Snesrud E 

PROVIDER: S-EPMC6105811 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Chromosomally Encoded <i>mcr-5</i> in Colistin-Nonsusceptible Pseudomonas aeruginosa.

Snesrud Erik E   Maybank Rosslyn R   Kwak Yoon I YI   Jones Anthony R AR   Hinkle Mary K MK   McGann Patrick P  

Antimicrobial agents and chemotherapy 20180727 8

Whole-genome sequencing (WGS) of historical <i>Pseudomonas aeruginosa</i> clinical isolates identified a chromosomal copy of <i>mcr-5</i> within a Tn<i>3</i>-like transposon in <i>P. aeruginosa</i> MRSN 12280. The isolate was nonsusceptible to colistin by broth microdilution, and genome analysis revealed no mutations known to confer colistin resistance. To the best of our knowledge, this is the first report of <i>mcr</i> in colistin-nonsusceptible <i>P. aeruginosa</i>. ...[more]

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