Ontology highlight
ABSTRACT:
SUBMITTER: Sampson CM
PROVIDER: S-EPMC6106167 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Sampson Catherine M CM Kasper James M JM Felsing Daniel E DE Raval Sweta R SR Ye Na N Wang Pingyuan P Patrikeev Igor I Rytting Erik E Zhou Jia J Allen John A JA Hommel Jonathan D JD
Pharmacology research & perspectives 20180823 5
Obesity is a growing public health concern, with 37.5% of the adult population in need of therapeutics that are more efficacious with a better side effect profile. An innovative target in this regard is neuromedin U, a neuropeptide shown to suppress food intake and attenuate weight gain in animal models. These effects of neuromedin U on feeding behavior are thought to be related to agonism at the centrally expressed neuromedin U receptor 2 (NMUR2). As peptides present unique challenges that limi ...[more]