Multiple Molecular Mechanisms Rescue mtDNA Disease in C. elegans.
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ABSTRACT:
SUBMITTER: Haroon S
PROVIDER: S-EPMC6106782 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Publications
Multiple Molecular Mechanisms Rescue mtDNA Disease in C. elegans.
Haroon Suraiya S Li Annie A Weinert Jaye L JL Fritsch Clark C Ericson Nolan G NG Alexander-Floyd Jasmine J Braeckman Bart P BP Haynes Cole M CM Bielas Jason H JH Gidalevitz Tali T Vermulst Marc M
Cell reports 20180301 12
Genetic instability of the mitochondrial genome (mtDNA) plays an important role in human aging and disease. Thus far, it has proven difficult to develop successful treatment strategies for diseases that are caused by mtDNA instability. To address this issue, we developed a model of mtDNA disease in the nematode C. elegans, an animal model that can rapidly be screened for genes and biological pathways that reduce mitochondrial pathology. These worms recapitulate all the major hallmarks of mtDNA d ...[more]
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