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Motor cortical oscillations are abnormally suppressed during repetitive movement in patients with Parkinson's disease.

ABSTRACT: Impaired repetitive movement in persons with Parkinson's disease (PD) is associated with reduced amplitude, paradoxical hastening and hesitations or arrest at higher movement rates. This study examined the effects of movement rate and medication on movement-related cortical oscillations in persons with PD.Nine participants with PD were studied off and on medication and compared to nine control participants. Participants performed index finger movements cued by tones from 1 to 3 Hz. Movement-related oscillations were derived from electroencephalographic recordings over the region of the contralateral sensorimotor cortex (S1/M1) during rest, listening, or synchronized movement.At rest, spectral power recorded over the region of the contralateral S1/M1 was increased in the alpha band and decreased in the beta band in participants with PD relative to controls. During movement, the level of alpha and beta band power relative to baseline was significantly reduced in the PD group, off and on medication, compared to controls. Reduced movement amplitude and hastening at movement rates near 2 Hz was associated with abnormally suppressed and persistent desynchronization of oscillations in alpha and beta bands.Motor cortical oscillations in the alpha and beta bands are abnormally suppressed in PD, particularly during higher rate movements.These findings contribute to the understanding of mechanisms underlying impaired repetitive movement in PD.

SUBMITTER: Stegemoller EL

PROVIDER: S-EPMC6106791 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature

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Motor cortical oscillations are abnormally suppressed during repetitive movement in patients with Parkinson's disease.

Stegemöller Elizabeth L EL Allen David P DP Simuni Tanya T MacKinnon Colum D CD

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 20150529 1

<h4>Objective</h4>Impaired repetitive movement in persons with Parkinson's disease (PD) is associated with reduced amplitude, paradoxical hastening and hesitations or arrest at higher movement rates. This study examined the effects of movement rate and medication on movement-related cortical oscillations in persons with PD.<h4>Methods</h4>Nine participants with PD were studied off and on medication and compared to nine control participants. Participants performed index finger movements cued by t ...[more]

PMID: 26089232

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Project description:Recent electrocorticography data have demonstrated excessive coupling of beta-phase to gamma-amplitude in primary motor cortex and that deep brain stimulation facilitates motor improvement by decreasing baseline phase-amplitude coupling. However, both the dynamic modulation of phase-amplitude coupling during movement and the general cortical neurophysiology of other movement disorders, such as essential tremor, are relatively unexplored. To clarify the relationship of these interactions in cortical oscillatory activity to movement and disease state, we recorded local field potentials from hand sensorimotor cortex using subdural electrocorticography during a visually cued, incentivized handgrip task in subjects with Parkinson's disease (n = 11), with essential tremor (n = 9) and without a movement disorder (n = 6). We demonstrate that abnormal coupling of the phase of low frequency oscillations to the amplitude of gamma oscillations is not specific to Parkinson's disease, but also occurs in essential tremor, most prominently for the coupling of alpha to gamma oscillations. Movement kinematics were not significantly different between these groups, allowing us to show for the first time that robust alpha and beta desynchronization is a shared feature of sensorimotor cortical activity in Parkinson's disease and essential tremor, with the greatest high-beta desynchronization occurring in Parkinson's disease and the greatest alpha desynchronization occurring in essential tremor. We also show that the spatial extent of cortical phase-amplitude decoupling during movement is much greater in subjects with Parkinson's disease and essential tremor than in subjects without a movement disorder. These findings suggest that subjects with Parkinson's disease and essential tremor can produce movements that are kinematically similar to those of subjects without a movement disorder by reducing excess sensorimotor cortical phase-amplitude coupling that is characteristic of these diseases.

Dataset Information

Motor cortical oscillations are abnormally suppressed during repetitive movement in patients with Parkinson's disease.

Publications

Motor cortical oscillations are abnormally suppressed during repetitive movement in patients with Parkinson's disease.

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