Dataset Information

Single-shot real-time femtosecond imaging of temporal focusing.

ABSTRACT: While the concept of focusing usually applies to the spatial domain, it is equally applicable to the time domain. Real-time imaging of temporal focusing of single ultrashort laser pulses is of great significance in exploring the physics of the space-time duality and finding diverse applications. The drastic changes in the width and intensity of an ultrashort laser pulse during temporal focusing impose a requirement for femtosecond-level exposure to capture the instantaneous light patterns generated in this exquisite phenomenon. Thus far, established ultrafast imaging techniques either struggle to reach the desired exposure time or require repeatable measurements. We have developed single-shot 10-trillion-frame-per-second compressed ultrafast photography (T-CUP), which passively captures dynamic events with 100-fs frame intervals in a single camera exposure. The synergy between compressed sensing and the Radon transformation empowers T-CUP to significantly reduce the number of projections needed for reconstructing a high-quality three-dimensional spatiotemporal datacube. As the only currently available real-time, passive imaging modality with a femtosecond exposure time, T-CUP was used to record the first-ever movie of non-repeatable temporal focusing of a single ultrashort laser pulse in a dynamic scattering medium. T-CUP's unprecedented ability to clearly reveal the complex evolution in the shape, intensity, and width of a temporally focused pulse in a single measurement paves the way for single-shot characterization of ultrashort pulses, experimental investigation of nonlinear light-matter interactions, and real-time wavefront engineering for deep-tissue light focusing.

SUBMITTER: Liang J

PROVIDER: S-EPMC6107054 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Single-shot real-time femtosecond imaging of temporal focusing.

Liang Jinyang J Zhu Liren L Wang Lihong V LV

Light, science & applications 20180808

While the concept of focusing usually applies to the spatial domain, it is equally applicable to the time domain. Real-time imaging of temporal focusing of single ultrashort laser pulses is of great significance in exploring the physics of the space-time duality and finding diverse applications. The drastic changes in the width and intensity of an ultrashort laser pulse during temporal focusing impose a requirement for femtosecond-level exposure to capture the instantaneous light patterns genera ...[more]

PMID: 30839588

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Project description:PurposeTo develop EPTI, a multi-shot distortion-free multi-echo imaging technique, into a single-shot acquisition to achieve improved robustness to motion and physiological noise, increased temporal resolution, and high SNR efficiency for dynamic imaging applications.MethodsA new spatiotemporal encoding was developed to achieve single-shot EPTI by enhancing spatiotemporal correlation in k-t space. The proposed single-shot encoding improves reconstruction conditioning and sampling efficiency, with additional optimization under various accelerations to achieve optimized performance. To achieve high SNR efficiency, continuous readout with minimized deadtime was employed that begins immediately after excitation and extends for an SNR-optimized length. Moreover, k-t partial Fourier and simultaneous multi-slice acquisition were integrated to further accelerate the acquisition and achieve high spatial and temporal resolution.ResultsWe demonstrated that ss-EPTI achieves higher tSNR efficiency than multi-shot EPTI, and provides distortion-free imaging with densely-sampled multi-echo images at resolutions ~1.25-3 mm at 3T and 7T-with high SNR efficiency and with comparable temporal resolutions to ss-EPI. The ability of ss-EPTI to eliminate dynamic distortions common in EPI also further improves temporal stability. For fMRI, ss-EPTI also provides early-TE images (e.g., 2.9ms) to recover signal-intensity and functional-sensitivity dropout in challenging regions. The multi-echo images provide TE-dependent information about functional fluctuations, successfully distinguishing noise-components from BOLD signals and further improving tSNR. For diffusion MRI, ss-EPTI provides high-quality distortion-free diffusion images and multi-echo diffusion metrics.Conclusionss-EPTI provides distortion-free imaging with high image quality, rich multi-echo information, and enhanced efficiency within comparable temporal resolution to ss-EPI, offering a robust and efficient acquisition for dynamic imaging.

Dataset Information

Single-shot real-time femtosecond imaging of temporal focusing.

Publications

Single-shot real-time femtosecond imaging of temporal focusing.

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