Wearable Contact Lens Biosensors for Continuous Glucose Monitoring Using Smartphones.

ABSTRACT: Low-cost, robust, and reusable continuous glucose monitoring systems that can provide quantitative measurements at point-of-care settings is an unmet medical need. Optical glucose sensors require complex and time-consuming fabrication processes, and their readouts are not practical for quantitative analyses. Here, a wearable contact lens optical sensor was created for the continuous quantification of glucose at physiological conditions, simplifying the fabrication process and facilitating smartphone readouts. A photonic microstructure having a periodicity of 1.6 μm was printed on a glucose-selective hydrogel film functionalized with phenylboronic acid. Upon binding with glucose, the microstructure volume swelled, which modulated the periodicity constant. The resulting change in the Bragg d

SUBMITTER: Elsherif M 

PROVIDER: S-EPMC6107296 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature