The germline genetic component of drug sensitivity in cancer cell lines.
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ABSTRACT:
SUBMITTER: Menden MP
PROVIDER: S-EPMC6107640 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Publications
The germline genetic component of drug sensitivity in cancer cell lines.
Menden Michael P MP Casale Francesco Paolo FP Stephan Johannes J Bignell Graham R GR Iorio Francesco F McDermott Ultan U Garnett Mathew J MJ Saez-Rodriguez Julio J Stegle Oliver O
Nature communications 20180823 1
Patients with seemingly the same tumour can respond very differently to treatment. There are strong, well-established effects of somatic mutations on drug efficacy, but there is at-most anecdotal evidence of a germline component to drug response. Here, we report a systematic survey of how inherited germline variants affect drug susceptibility in cancer cell lines. We develop a joint analysis approach that leverages both germline and somatic variants, before applying it to screening data from 993 ...[more]
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