Ontology highlight
ABSTRACT: Background
The safety of iron supplementation for young women is uncertain in malaria-endemic settings.Methods
This was a double-blind, randomized controlled noninferiority trial in rural Burkina Faso.Results
A total of 1959 nulliparae were assigned to weekly supplementation (60 mg iron and 2.8 mg folic acid) (n = 980) or 2.8 mg folic acid (n = 979) until first antenatal visit (ANC1), or 18 months if remaining nonpregnant. Three hundred fifteen women attended ANC1, and 916 remained nonpregnant. There was no difference at ANC1 in parasitemia prevalence (iron, 53.4% [95% confidence interval {CI}, 45.7%-61.0%]; control, 55.3% [95% CI, 47.3%-62.9%]; prevalence ratio, 0.97 [95% CI, .79-1.18]; P = .82), anemia (adjusted effect, 0.96 [95% CI, .83-1.10]; P = .52), iron deficiency (adjusted risk ratio [aRR], 0.84 [95% CI, .46-1.54]; P = .58), or plasma iron biomarkers. Outcomes in nonpregnant women were parasitemia (iron, 42.9% [95% CI, 38.3%-47.5%]; control, 39.2% [95% CI, 34.9%-43.7%]; prevalence ratio, 1.09 [95% CI, .93-1.28]; P = .282); anemia (aRR, 0.90 [95% CI, .78-1.05]; P = .17), and iron deficiency (aRR, 0.99 [95% CI, .77-1.28]; P = .96), with no iron biomarker differences.Conclusions
Weekly iron supplementation did not increase malaria risk, improve iron status, or reduce anemia in young, mostly adolescent menstruating women, nor in early pregnancy. World Health Organization Guidelines for universal supplementation for young nulliparous women may need reassessment.Clinical trials registration
NCT01210040.
SUBMITTER: Gies S
PROVIDER: S-EPMC6107738 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Gies Sabine S Diallo Salou S Roberts Stephen A SA Kazienga Adama A Powney Matthew M Brabin Loretta L Ouedraogo Sayouba S Swinkels Dorine W DW Geurts-Moespot Anneke J AJ Claeys Yves Y D'Alessandro Umberto U Tinto Halidou H Faragher Brian B Brabin Bernard B
The Journal of infectious diseases 20180801 7
<h4>Background</h4>The safety of iron supplementation for young women is uncertain in malaria-endemic settings.<h4>Methods</h4>This was a double-blind, randomized controlled noninferiority trial in rural Burkina Faso.<h4>Results</h4>A total of 1959 nulliparae were assigned to weekly supplementation (60 mg iron and 2.8 mg folic acid) (n = 980) or 2.8 mg folic acid (n = 979) until first antenatal visit (ANC1), or 18 months if remaining nonpregnant. Three hundred fifteen women attended ANC1, and 91 ...[more]