Cyclosporine-A induces endoplasmic reticulum stress in human gingival fibroblasts - An in vitro study.
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ABSTRACT:
SUBMITTER: Rao SR
PROVIDER: S-EPMC6108159 | biostudies-literature | 2018 Sep-Dec
REPOSITORIES: biostudies-literature
Publications
Cyclosporine-A induces endoplasmic reticulum stress in human gingival fibroblasts - An in vitro study.
Rao Suresh Ranga SR Ajitkumar Supraja S Subbarayan Rajasekaran R Girija Dinesh Murugan DM
Journal of oral biology and craniofacial research 20161222 3
Drug induced gingival overgrowth is one of the side effects affecting the gingiva due to administration of certain systemic drugs. Cyclosporine A is one such drug which is commonly used in organ transplant conditions. The resultant overgrowth is fibrotic and extensive in nature which could impair patient esthetics and masticatory function. Endoplasmic reticulum stress is a recently identified phenomenon implicated in other fibrotic pathologies such as lung and renal fibrosis. In fact, endoplasmi ...[more]
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