Ontology highlight
ABSTRACT:
SUBMITTER: Pinger J
PROVIDER: S-EPMC6108419 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Pinger Jason J Nešić Dragana D Ali Liaqat L Aresta-Branco Francisco F Lilic Mirjana M Chowdhury Shanin S Kim Hee-Sook HS Verdi Joseph J Raper Jayne J Ferguson Michael A J MAJ Papavasiliou F Nina FN Stebbins C Erec CE
Nature microbiology 20180709 8
The African trypanosome Trypanosoma brucei spp. is a paradigm for antigenic variation, the orchestrated alteration of cell surface molecules to evade host immunity. The parasite elicits robust antibody-mediated immune responses to its variant surface glycoprotein (VSG) coat, but evades immune clearance by repeatedly accessing a large genetic VSG repertoire and 'switching' to antigenically distinct VSGs. This persistent immune evasion has been ascribed exclusively to amino-acid variance on the VS ...[more]